Roots of Lithospermum erythrorhizon Alleviated Ovalbumin-Induced Allergic Rhinitis and IgE-triggered Degranulation of RBL-2H3 Cells

Lithospermum erythrorhizon (L. erythrorhizon) root is used in traditional medicine for its anti-inflammatory, antibacterial, and antioxidant properties. However, no studies have examined impact on allergic rhinitis (AR). Here, we explored the protective effects of L. immunoglobulin E (IgE)-stimulated RBL-2H3 cells an ovalbumin (OVA)-induced AR mouse model. In latter, nasal mucosal inflammation, allergen-specific cytokine production, histological changes to mucosa. model, oral administration ethanol extract (LE) led a marked reduction rubbing sneeze frequency, significant decrease serum OVA-specific IgE IgG1 levels, increase IgG2a/IgG1 ratio. LE also reduced expression interleukin (IL)-4, IL-5, IL-13 lavage fluid (NALF), suppressed inflammatory cell infiltration epithelial degradation tissues. IgE-stimulated cells, release degranulation markers such as β-hexosaminidase histamine. Based these findings, suggest that may ameliorate OVA-induced by regulating mast cell-mediated responses.